Androgenic alopecia in men: the significance of genetic, hormonal and metabolic factors (prospective cohort comparative study)

BACKGROUND: diagnosis and treatment of androgenetic alopecia in male patients is a topical issue modern dermatology, this due to the high prevalence disease population, complexity therapy. In most cases, pathogenesis associated with genetic factors, not paying attention totality non-genetic factors that affect occurrence development patients.
 AIM: study pathogenetic mechanisms androgenic men on basis comprehensive account genetic, hormonal metabolic factors.
 MATERIAL AND METHODS: Genetic predisposition was evaluated by method minisequencing, evaluation nongenetic ― using validated methods. Further finalizing research results carried out neural network step-by-step linear discriminate analysis.
 RESULTS: The included 50 verified Androgenic alopecia, stages from I IV Norwood-Hamilton scale, 25 volunteers corresponding age nationality. nucleotide polymorphisms made it possible assess potentially low level risk disease. initial zinc turned be significant for assessing prognosis effectiveness Mono- or polydeficiency zinc, copper, magnesium, selenium, vitamins D, B12, E, folic acid play role disease.
 CONCLUSIONS: show different patients.